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Rueda, J
When lost quickly, the underlying scaffolding disappears, and the skin as well as the supporting collagen and elastin may not adapt in time, leading to sagging, deeper folds, and a deflated appearance often described as Ozempic face. Common facial changes associated with GLP-1-driven weight loss include: Sunken cheeks and temples Sagging jowls and jawline Deepening of nasolabial folds (smile lines) Downturned corners of the mouth Flattened or elongated lips Excess skin and loss of facial volume These changes result not only from fat loss but also from the skins decreased elasticity that occurs with both aging and accelerated weight reduction
Current evidence suggests it plays an important role in supporting: Healthy metabolism Insulin sensitivity Appetite regulation Body weight regulation Long-term cardiometabolic health Rather than viewing GLP-1 as simply a "weight-loss hormone," pediatric endocrinologists recognize it as an important part of the body's complex metabolic system
L.StewartM.CirkelD
